When standard antidepressants and talk therapy haven’t provided relief, you may be experiencing treatment-resistant depression (TRD).

At Hawaii Wellness, our Treatment-Resistant Depression Therapy Specialists in Hawaii offer cutting-edge, integrative solutions combining rapid-acting Ketamine Therapy with supportive modalities to help you break through persistent depressive cycles and regain hope.

What Is Treatment-Resistant Depression?

Treatment-resistant depression is defined as major depressive episodes that don’t sufficiently improve after two or more adequate antidepressant trials. Symptoms often include:

  • Persistent low mood lasting months or years
  • Lack of response to multiple medications or therapies
  • Suicidal ideation or severe functional impairment
  • Cognitive fog, anhedonia (inability to feel pleasure), and fatigue

TRD requires a more targeted strategy to address underlying neurochemical and neuroplasticity deficits.

Our Integrated Approach

As leading Treatment-Resistant Depression Therapy Specialists in Hawaii, we offer:

Ketamine Therapy

Low-dose infusions modulate NMDA receptors and prompt BDNF release. Standard courses of six infusions (twice weekly over three weeks) or accelerated options for urgent cases. Maintenance dosing helps sustain gains.

Neurofeedback & qEEG Brain Mapping

Real-time EEG feedback helps normalize dysregulated patterns (e.g., excessive theta or beta activity), reinforcing emotional stability and cognitive clarity.

IV Nutrient Support

IV B-complex vitamins, magnesium, and antioxidants (like glutathione) correct deficiencies that exacerbate depression and support neurotransmitter synthesis.

NAD⁺ Therapy for Cellular Rejuvenation

NAD⁺ infusions enhance ATP production and stimulate DNA repair counteracting chronic stress effects and boosting cognitive energy.

Why Choose Hawaii Wellness?

  • Expert Clinical Team – Board-certified anesthesiologists, psychiatrists, and licensed clinicians specializing in TRD protocols.
  • Customized Treatment Plans – Every plan is tailored based on your history of antidepressant trials, qEEG findings, and lab work, ensuring precise interventions for lasting improvement.
  • Holistic, Outcomes-Focused Care – By integrating Ketamine, neurofeedback, IV nutrients, and NAD⁺, we address both neurochemical imbalances and lifestyle factors contributing to TRD.

Get Started Today

Our Treatment-Resistant Depression Therapy Specialists in Hawaii are here to guide you toward meaningful relief and renewed purpose.